Impact of prematurity on lifelong cardiovascular health: structural and functional considerations

Sixtus, Ryan ORCID: https://orcid.org/0000-0002-2041-8928, Dyson, Rebecca and Gray, Clint 2024. Impact of prematurity on lifelong cardiovascular health: structural and functional considerations. npj Cardiovascular Health 1 , 2. 10.1038/s44325-024-00002-0

Preview

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB) | Preview

Abstract

The aetiology of preterm cardiovascular disease formation appears different from that of traditional population. Within the ‘traditional’ population cardiovascular disease formation is driven by functional stressors (e.g., diet, smoking). Whereas preterm cardiovascular disease risk is driven by structural changes incurred at birth. Much of the proliferative growth in the developing heart and major vessels ceases at birth, leading to permanently reduced dimensions compared to their term-born cohort. These structural changes take a back seat to functional and clinical complications within the neonatal period, but become increasingly pronounced from adolescence, at which point functional decompensation can be observed. While the cause may differ from ‘traditional’ populations, the eventual disease outcomes do not, leading them to be an overlooked population. This means that aetiology, and thus, treatment options may be very different due to the underlying mechanisms. Here, we propose that the structural cause of preterm-associated cardiovascular disease is apparent and observable early in life. Understanding the differences in cardiovascular disease aetiology may therefore aid in the early treatment of preterm-associated cardiovascular disease risk.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Subjects:	Q Science > QP Physiology R Medicine > RA Public aspects of medicine > RA0421 Public health. Hygiene. Preventive Medicine R Medicine > RJ Pediatrics
Publisher:	Nature Research
ISSN:	2948-2836
Funders:	BBSRC
Date of First Compliant Deposit:	5 April 2024
Date of Acceptance:	20 February 2024
Last Modified:	17 Apr 2024 13:30
URI:	https://orca.cardiff.ac.uk/id/eprint/167748

Actions (repository staff only)

Edit Item