Advancements in spinal cord injury repair: Insights from dental-derived stem cells

Wen, Xueying, Jiang, Wenkai, Li, Xiaolin, Liu, Qian, Kang, Yuanyuan and Song, Bing ORCID: https://orcid.org/0000-0001-9356-2333 2024. Advancements in spinal cord injury repair: Insights from dental-derived stem cells. Biomedicines 12 (3) , 683. 10.3390/biomedicines12030683

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Abstract

Spinal cord injury (SCI), a prevalent and disabling neurological condition, prompts a growing interest in stem cell therapy as a promising avenue for treatment. Dental-derived stem cells, including dental pulp stem cells (DPSCs), stem cells from human exfoliated deciduous teeth (SHED), stem cells from the apical papilla (SCAP), dental follicle stem cells (DFSCs), are of interest due to their accessibility, minimally invasive extraction, and robust differentiating capabilities. Research indicates their potential to differentiate into neural cells and promote SCI repair in animal models at both tissue and functional levels. This review explores the potential applications of dental-derived stem cells in SCI neural repair, covering stem cell transplantation, conditioned culture medium injection, bioengineered delivery systems, exosomes, extracellular vesicle treatments, and combined therapies. Assessing the clinical effectiveness of dental-derived stem cells in the treatment of SCI, further research is necessary. This includes investigating potential biological mechanisms and conducting Large-animal studies and clinical trials. It is also important to undertake more comprehensive comparisons, optimize the selection of dental-derived stem cell types, and implement a functionalized delivery system. These efforts will enhance the therapeutic potential of dental-derived stem cells for repairing SCI.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Dentistry
Additional Information:	License information from Publisher: LICENSE 1: URL: https://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	MDPI
Date of First Compliant Deposit:	8 April 2024
Date of Acceptance:	26 February 2024
Last Modified:	08 Apr 2024 09:45
URI:	https://orca.cardiff.ac.uk/id/eprint/167788

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