Continuous flow electroselenocyclization of allylamides and Unsaturated Oximes to selenofunctionalized oxazolines and isoxazolines

Alzaidi, Ohud and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2024. Continuous flow electroselenocyclization of allylamides and Unsaturated Oximes to selenofunctionalized oxazolines and isoxazolines. ACS Organic & Inorganic Au 4 (3) , pp. 350-355. 10.1021/acsorginorgau.4c00008

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Abstract

The synthesis of selenofunctionalized oxazolines and isoxazolines from N-allyl benzamides and unsaturated oximes with diselenides was studied by utilizing a continuous flow electrochemical approach. At mild reaction conditions and short reaction times of 10 min product yields of up to 90% were achieved including a scale-up reaction. A broad substrate scope was studied and the reaction was shown to have a wide functional group tolerance.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	American Chemical Society
ISSN:	2694-247X
Date of First Compliant Deposit:	8 April 2024
Date of Acceptance:	26 February 2024
Last Modified:	02 Jul 2024 14:08
URI:	https://orca.cardiff.ac.uk/id/eprint/167811

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