Aluminum-decorated MIL-100(Fe) nanozyme for the detection of glutathione

Cui, Lin, Zhao, Xinshuo, Zhang, Jiankang, Zhou, Zhan, Lin, Dong and Qin, Yong 2024. Aluminum-decorated MIL-100(Fe) nanozyme for the detection of glutathione. ACS Applied Nano Material 7 (5) , pp. 4764-4771. 10.1021/acsanm.3c05262 Item availability restricted.

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Abstract

Nanozymes are nanomaterials with natural enzyme characteristics, which are expected to be potential substitutes of traditional enzymes. In this study, the 1Al/MIL-100(Fe) nanozymes with excellent peroxidase-like activity were synthesized by the ultrathin modification (one-cycle Al2O3) strategy of atomic layer deposition, whose peroxidase-like activity is almost doubled compared with MIL-100(Fe) nanozymes. Investigation of the catalytic mechanism indicates that the increased amount of hydroxyl radical is responsible for the much-enhanced peroxidase-like activity of 1Al/MIL-100(Fe) nanozymes. Furthermore, the catalytic effect of the designed nanozymes is inhibited by glutathione through consuming the oxidized 3,3′,5,5′-tetramethylbenzidine in the reaction system. The 1Al/MIL-100(Fe) nanozymes also achieve the sensitive and selective detection of glutathione, which have an excellent linear response to glutathione concentration in the range 0.01–1000 μM with a detection limit of 2.2 nM. The ultrathin modification strategy can be potentially extended to synthesize other high-efficiency nanozyme materials.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Publisher:	American Chemical Society
ISSN:	2574-0970
Funders:	National Natural Science Foundation of China (22372130 and 22102131) and Fundamental Research Funds for the Central Universities (G2023KY0605)
Date of First Compliant Deposit:	9 April 2024
Date of Acceptance:	31 January 2024
Last Modified:	19 Apr 2024 21:29
URI:	https://orca.cardiff.ac.uk/id/eprint/167834

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