Synthesis, isomorphism, and polymorphism of new (2E,4E)-1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)-5-phenylpenta-2,4-dien-1-ones

Abdel-Wahab, Bakr F., Kariuki, Benson M. ORCID: https://orcid.org/0000-0002-8658-3897 and El-Hiti, Gamal A. 2024. Synthesis, isomorphism, and polymorphism of new (2E,4E)-1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)-5-phenylpenta-2,4-dien-1-ones. Journal of Molecular Structure 1304 , 137748. 10.1016/j.molstruc.2024.137748

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Abstract

The Claisen–Schmidt condensation of 1-aryl-4-acetyl-5-methyl-1,2,3-triazoles and trans-cinnamaldehyde in ethanolic sodium hydroxide (10 %) at room temperature gave (2E,4E)-1-(5-methyl-1-aryl-1H-1,2,3-triazol-4-yl)-5-phenylpenta-2,4‑dien-1-ones in high yields. The influence of fluoro, chloro, and nitro substituents on crystal packing has been assessed by exploring molecular electrostatic properties and intermolecular interactions. Close C–H…O, C–H…N, and C–H…π interactions occur in these compounds. Isomorphism and polymorphism have been observed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Publisher:	Elsevier
ISSN:	0022-2860
Date of First Compliant Deposit:	9 April 2024
Date of Acceptance:	7 February 2024
Last Modified:	08 Feb 2025 02:45
URI:	https://orca.cardiff.ac.uk/id/eprint/167835

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