Protists: Eukaryotic single-celled organisms and the functioning of their organelles

Yarlett, Nigel, Jarroll, Edward L., Morada, Mary and Lloyd, David ORCID: https://orcid.org/0000-0002-5656-0571 2024. Protists: Eukaryotic single-celled organisms and the functioning of their organelles. Advances in Microbial Physiology, Vol. 84. Academic Press Inc., pp. 1-66. (10.1016/bs.ampbs.2024.02.001)

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Abstract

Organelles are membrane bound structures that compartmentalize biochemical and molecular functions. With improved molecular, biochemical and microscopy tools the diversity and function of protistan organelles has increased in recent years, providing a complex panoply of structure/function relationships. This is particularly noticeable with the description of hydrogenosomes, and the diverse array of structures that followed, having hybrid hydrogenosome/mitochondria attributes. These diverse organelles have lost the major, at one time, definitive components of the mitochondrion (tricarboxylic cycle enzymes and cytochromes), however they all contain the machinery for the assembly of Fe-S clusters, which is the single unifying feature they share. The plasticity of organelles, like the mitochondrion, is therefore evident from its ability to lose its identity as an aerobic energy generating powerhouse while retaining key ancestral functions common to both aerobes and anaerobes. It is interesting to note that the apicoplast, a non-photosynthetic plastid that is present in all apicomplexan protozoa, apart from Cryptosporidium and possibly the gregarines, is also the site of Fe-S cluster assembly proteins. It turns out that in Cryptosporidium proteins involved in Fe-S cluster biosynthesis are localized in the mitochondrial remnant organelle termed the mitosome. Hence, different organisms have solved the same problem of packaging a life-requiring set of reactions in different ways, using different ancestral organelles, discarding what is not needed and keeping what is essential. Don’t judge an organelle by its cover, more by the things it does, and always be prepared for surprises.

Item Type:	Book Section
Date Type:	Published Online
Status:	In Press
Schools:	Biosciences
Publisher:	Academic Press Inc.
ISSN:	0065-2911
Last Modified:	13 May 2024 10:12
URI:	https://orca.cardiff.ac.uk/id/eprint/168172

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