Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination

O'Brien, Oisín, Arumuham, Atheeshaan, Mizuno, Yuya, Baxter, Luke, Lobo, Maria, Parmar, Sita, Jolles, Stephen and Howes, Oliver D. 2024. Immune response to vaccination in people with psychotic disorders relative to healthy controls: prospective study of SARS-CoV-2 vaccination. BJPsych Open 10 (2) , e49. 10.1192/bjo.2024.10

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Abstract

This prospective study examines the immune response to SARS-CoV-2 vaccination in patients with psychotic disorders compared with healthy volunteers. Participants were recruited naturalistically as part of the UK's COVID-19 vaccination programme. Prior to receiving their first COVID-19 vaccine, blood samples were provided by participants to examine anti-SARS-CoV-2 immunoglobulins (IgG) at baseline, followed by a repeat assay 1 month after receiving their first vaccine to assess vaccine response. The increase of IgG levels from baseline to 1 month post-vaccination was significantly lower in patients compared with controls, supporting evidence of impaired vaccine response in people with psychotic disorders. When excluding patients treated with clozapine from the analysis, this difference was no longer significant, suggesting that effects may be particularly marked in people taking clozapine.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	Cambridge University Press
ISSN:	2056-4724
Funders:	N/A
Date of First Compliant Deposit:	10 May 2024
Date of Acceptance:	18 January 2024
Last Modified:	10 May 2024 10:15
URI:	https://orca.cardiff.ac.uk/id/eprint/168218

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