Investigating the causal risk factors for self-harm by integrating Mendelian randomisation within twin modelling

Lim, Kai Xiang, Oginni, Olakunle Ayokunmi, Rimfeld, Kaili, Pingault, Jean-Baptiste and Rijsdijk, Frühling 2022. Investigating the causal risk factors for self-harm by integrating Mendelian randomisation within twin modelling. Behavior Genetics 52 (6) , 324–337. 10.1007/s10519-022-10114-x

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Abstract

Previous genetically informed studies have uncovered likely causal relationships between mental health problems and self-harm but resulting causal estimates may be biased due to unmediated pleiotropy. By fitting Mendelian Randomization - Direction of Causation (MR-DoC) models that explicitly model pleiotropy, we investigated the effect of four quantitatively measured mental health problems - major depressive disorder (MDD), schizophrenia, attention-deficit hyperactivity disorder (ADHD), and insomnia, on non-suicidal self-harm (NSSH) and suicidal self-harm (SSH), separately. We used data of 12,723 twins (56.6% females) in the Twins Early Development Study. Besides substantial pleiotropy, we found effects from child-rated depressive symptoms to both NSSH (β = 0.194, 95% CIs: 0.131, 0.257) and SSH (β = 0.210, 95% CIs: 0.125, 0.295). Similarly, effects flowed from parent-rated depressive symptoms to NSSH (β = 0.092, 95% CIs: 0.004, 0.181) and SSH (β = 0.165, 95% CIs: 0.051, 0.281). We did not find evidence of aetiological difference between NSSH and SSH.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Springer
ISSN:	0001-8244
Date of Acceptance:	14 August 2022
Last Modified:	22 May 2024 11:00
URI:	https://orca.cardiff.ac.uk/id/eprint/168277

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