Phenotypic and genetic heterogeneity within biofilms with particular emphasis on persistence and antimicrobial tolerance.

Sadiq, Faizan Ahmed ORCID: https://orcid.org/0000-0003-1596-4155, Flint, Steve, Li, YanJun, Ou, Kai, Yuan, Lei and He, Guo Qing 2017. Phenotypic and genetic heterogeneity within biofilms with particular emphasis on persistence and antimicrobial tolerance. Future Microbiology 12 (12) , pp. 1087-1107. 10.2217/fmb-2017-0042

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Abstract

Phenotypic changes or phase variation within biofilms is an important feature of bacterial dormant life. Enhanced resistance to antimicrobials is one of the distinct features displayed by a fraction of cells within biofilms. It is believed that persisters are mainly responsible for this phenotypic heterogeneity. However, there is still an unresolved debate on the formation of persisters. In this short review, we highlight all known genomic and proteomic changes encountered by bacterial cells within biofilms. We have also described all phenotypic changes displayed by bacterial cells within biofilms with particular emphasis on enhanced antimicrobial tolerance of biofilms with particular reference to persisters. In addition, all currently known models of persistence have been succinctly discussed.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Dentistry
Publisher:	Future Science Group
ISSN:	1746-0913
Date of Acceptance:	30 May 2017
Last Modified:	03 May 2024 01:28
URI:	https://orca.cardiff.ac.uk/id/eprint/168400

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