Electronically preresonant stimulated Raman scattering microscopy in the visible

Choorakuttil, A. J. X., Pruccoli, A., Winterhalder, M. J., Zirak, P., Gudavicius, Dominykas, Martynaitis, G., Petrulionis, D., Samsonas, D., Kontenis, L. and Zumbusch, A. 2023. Electronically preresonant stimulated Raman scattering microscopy in the visible. Applied Physics Letters 123 (16) , 163701. 10.1063/5.0171725

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Abstract

We report an experimental scheme for stimulated Raman scattering (SRS) microscopy with excitation in the visible spectral region. This allows electronically preresonant (epr) SRS microscopy of a broad range of chromophores with sensitivities as low as 1 μM. Our experiment is based on two synchronously near-infrared pumped optical parametric oscillators (OPO). One of the outputs is modulated at a fourth of the repetition rate with a novel broadband electro-optical modulator. Using a combination of spectral focusing and tuning of the OPO, we show the recording of epr-SRS spectra over the whole range of molecular vibrations at a speed up to 20 times faster than classical wavelength tuning. The imaging capabilities of this setup are demonstrated with material scientific and cellular samples.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Physics and Astronomy
Publisher:	American Institute of Physics
ISSN:	0003-6951
Date of First Compliant Deposit:	30 April 2024
Date of Acceptance:	30 September 2023
Last Modified:	30 Apr 2024 09:16
URI:	https://orca.cardiff.ac.uk/id/eprint/168487

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