Diagnosis, prognostic factors and assessment of ALL in adults: 2023 ELN recommendations from a European Expert Panel

Gökbuget, Nicola, Boissel, Nicolas, Chiaretti, Sabina, Dombret, Herve, Doubek, Michael, Fielding, Adele K., Foà, Robin, Giebel, Sebastian, Hoelzer, Dieter, Hunault, Mathilde, Marks, David I, Martinelli, Giovanni, Ottmann, Oliver G. ORCID: https://orcid.org/0000-0001-9559-1330, Rijneveld, Anita W., Rousselot, Philippe, Ribera, Josep-Maria and Bassan, Renato 2024. Diagnosis, prognostic factors and assessment of ALL in adults: 2023 ELN recommendations from a European Expert Panel. Blood 143 (19) , pp. 1891-1902. 10.1182/blood.2023020794

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Abstract

Working groups of the European Leukemia Net (ELN) have published several important consensus guidelines. Acute lymphoblastic leukemia (ALL) has many different clinical and biological subgroups and the knowledge on disease biology and therapeutic options is increasing exponentially. The European Working Group for Adult ALL has therefore summarized the current state of the art and provided comprehensive consensus recommendations for diagnostic approaches, biologic and clinical characterization, prognostic factors and risk stratification as well as definitions of endpoints and outcomes. Aspects of treatment, management of subgroups and specific situations, aftercare and supportive care are covered in a separate publication. The present recommendation intends to provide guidance for the initial management of adult ALL patients and to define principles as a basis for future collaborative research.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	American Society of Hematology (ASH Publications)
ISSN:	0006-4971
Date of First Compliant Deposit:	3 May 2024
Date of Acceptance:	21 January 2024
Last Modified:	09 Nov 2024 20:45
URI:	https://orca.cardiff.ac.uk/id/eprint/168701

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