Using our understanding of interactions between helminth metabolism and host immunity to target worm survival

Reed, Ella Katie and Smith, Katherine Ann ORCID: https://orcid.org/0000-0001-8150-5702 2024. Using our understanding of interactions between helminth metabolism and host immunity to target worm survival. Trends in Parasitology 40 (7) , pp. 549-561. 10.1016/j.pt.2024.05.006

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Abstract

Helminths can adapt to environmental conditions in the host, utilising anaerobic processes like fermentation and malate dismutation to produce energy from carbohydrate. Although targeting carbohydrate metabolism is an established therapeutic strategy to combat helminth infection, questions remain over the metabolic pathways they employ as adults to survive and evade host immunity. Helminths also use amino acid, polyunsaturated fatty acid (PUFA), and cholesterol metabolism, a possible strategy favouring the production of immunomodulatory compounds that may influence survival in the host. Here, we discuss the significance of these differing metabolic pathways and whether targeting of helminth metabolic pathways may allow for the development of novel anthelmintics.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Cell Press
ISSN:	1471-4922
Date of First Compliant Deposit:	13 May 2024
Date of Acceptance:	12 May 2024
Last Modified:	08 Jun 2025 01:45
URI:	https://orca.cardiff.ac.uk/id/eprint/168881

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