Fast X-ray ptychography: towards nanoscale imaging of large volume of brain

Cipiccia, Silvia, Fratini, Michela, Erin, Ecem, Palombo, Marco ORCID: https://orcid.org/0000-0003-4892-7967, Vogel, Silvia, Burian, Max, Zhou, Fenglei, Parker, Geoff J. M. and Batey, Darren J. 2024. Fast X-ray ptychography: towards nanoscale imaging of large volume of brain. European Physical Journal Plus 139 (5) , 434. 10.1140/epjp/s13360-024-05224-w

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Abstract

X-ray ptychography, a scanning coherent diffraction imaging technique, is one of the most used techniques at synchrotron facilities for high resolution imaging, with applications spanning from life science to nano-electronics. In the recent years there has been a great effort to make the technique faster to enable high throughput nanoscale imaging. Here we apply a fast ptychography scanning method to image in 3D 106μm3 of brain-like phantom at 3 kHz, in a 7 h acquisition with a resolution of 270 nm. We then present the latest advances in fast ptychography by showing 2D images acquired at 110 kHz by combining the fast-acquisition scheme with a high-acquisition rate prototype detector from DECTRIS Ltd. We finally review the experimental outcome and discuss the prospective use of fast ptychography schemes for the investigation of mm3 size samples of brain-like phantom, by extrapolating the current results to the high coherent flux scenario of diffraction limited storage rings.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Psychology
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by/4.0/, Type: open-access
Publisher:	Springer
Date of First Compliant Deposit:	23 May 2024
Date of Acceptance:	28 April 2024
Last Modified:	23 May 2024 13:45
URI:	https://orca.cardiff.ac.uk/id/eprint/169122

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