In vitro anticancer, antioxidant, antimicrobial, antileishmanial, enzymes inhibition and in vivo anti-inflammatory activities of organotin(IV) derivatives of 4-bromophenoxyacetic acid

Rahim, Shahnaz, Sadiq, Abdul, Javed, Aneela, Kubicki, Maciej, Kariuki, Benson ORCID: https://orcid.org/0000-0002-8658-3897, Assad, Mohammad, Muhammad, Niaz, Fatima, Nighat, Khan, Momin, AlAsmari, Abdullah F. and Alasmari, Fawaz 2024. In vitro anticancer, antioxidant, antimicrobial, antileishmanial, enzymes inhibition and in vivo anti-inflammatory activities of organotin(IV) derivatives of 4-bromophenoxyacetic acid. Journal of Molecular Structure 1313 (5) , 138703. 10.1016/j.molstruc.2024.138703 Item availability restricted.

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Abstract

Organotin(IV) derivatives {(n-C4H9)3SnL (1), (CH3)3SnL (2), (n-C4H9)2SnL2 (3) and (CH3)2SnL2 (4)} of 4-bromophenoxyacetic acid (HL) were synthesized and characterized by elemental, FT-IR, NMR and single crystal XRD diffraction analyses. The carboxylate ligand showed bridging/chelating bidentate coordination. The complexes 1 and 2 have adopted polymeric chain structures consisting tin atoms in distorted trigonal bipyramidal geometry. Complex 3 has shown highest DPPH radical scavenging (IC50 = 33.46 µg/mL) and antileishmanial activity (IC50 = 27.06 µg/mL). Complex 3 was also the most efficient agent in acetylcholinesterase (IC50 = 5.12 µg/mL), butyrylcholinesterase (IC50 = 13.79 µg/mL) and Monoamine oxidase (IC50 = 8.50 µg/mL) inhibition assays. Complex 4 (IC50 = 18.73 µg/mL) was the most potent ABTS radical scavenger. Complex 1 with IC50 values of 27.50 and 71.32 µg/mL was the most efficient α-glucosidase and dipeptidyl peptidase-4 enzyme inhibitor, respectively. While complex 2 was found the most potent Cyclooxygenase-2 (7.81 µg/mL) and 5-Lioxygenase (6.69 µg/mL) inhibitor. MTT assay revealed highest inhibitory potency of complexes 4 (IC50 = 8.035 ± 0.05 μg/ml), and 1 (IC50 = 10.16±0.17μg/ml) towards the brain cancer cell line. The in vivo study performed on mice have shown potent anti-inflammatory effects of 1 and 2 comparable to the standard, indomethacin.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry
Additional Information:	License information from Publisher: LICENSE 1: Title: This article is under embargo with an end date yet to be finalised.
Publisher:	Elsevier
ISSN:	0022-2860
Date of First Compliant Deposit:	12 July 2024
Date of Acceptance:	20 May 2024
Last Modified:	09 Nov 2024 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/169154

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