Sex-dependent behavioral effects of chronic nicotine during adolescence evaluated in young adult rats tested in Hole-Board

Casarrubea, Maurizio, Aiello, Stefania, Crescimanno, Giuseppe, Cassar, Daniel, Busuttil, Zachary, Faulisi, Fabiana, Iacono, Antonio and Di Giovanni, Giuseppe 2024. Sex-dependent behavioral effects of chronic nicotine during adolescence evaluated in young adult rats tested in Hole-Board. Progress in Neuro-Psychopharmacology and Biological Psychiatry 133 , 111034. 10.1016/j.pnpbp.2024.111034

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Abstract

As one of the leading causes of death and serious illnesses, tobacco smoking remains a significant issue in modern societies. Many individuals smoke during adolescence, a trend that has been exacerbated by the prevalence of vaping among young people. In this context, studying the behavioral effects induced by nicotine administration in male and female rats, during the adolescent period, assumes great importance because it can help to better understand the dynamics underlying tobacco use in the two sexes. For this purpose, we employed 4 groups of rats, 2 male and 2 female groups, chronically treated with saline or nicotine 3 mg/kg i.p. for 30 days, spanning from postnatal day 30 to postnatal day 60. Utilizing quantitative analyses and T-pattern detection and analysis, our findings revealed a complex and multifaceted behavioral reorganization in adolescent rats subjected to chronic nicotine administration. Specifically, we observed an increase of anxiety in males and a reduction in females. The distinctive structural changes, induced by chronic nicotine in both sexes, have significant implications, from a translational perspective, for studies on nicotine dependence disorders.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	0278-5846
Date of First Compliant Deposit:	30 May 2024
Date of Acceptance:	22 May 2024
Last Modified:	31 May 2024 10:30
URI:	https://orca.cardiff.ac.uk/id/eprint/169272

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