Standardized protocols for clinical and histopathological characterization of hidradenitis suppurativa tissue specimens

Sampath, Ashwath Jonathan, Westerkam, Linnea L., Blum, Franklin R., Alhusayen, Raed, Bechara, Falk G., Caffrey, Julie, Carmona-Rivera, Carmelo, Chandran, Nisha Suyien, George, Ralph, Goldberg, Stephanie R., Gudjonsson, Johann E., Hansen, Scott L., Ingram, John R. ORCID: https://orcid.org/0000-0002-5257-1142, Kirby, Brian, Marzano, Angelo Valerio, Matusiak, Lukasz, Orgill, Dennis P., Prens, Errol, van der Zee, Hessel H., van Straalen, Kelsey R., Zouboulis, Christos C., Byrd, Angel S., Frew, John W., Anne Lowes, Michelle, Naik, Haley B., Sokumbi, Olayemi, Mi, Qing-Sheng, Miedema, Jayson R., Googe, Paul B. and Sayed, Christopher J. 2024. Standardized protocols for clinical and histopathological characterization of hidradenitis suppurativa tissue specimens. Journal of Investigative Dermatology 10.1016/j.jid.2024.02.041 Item availability restricted.

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Abstract

Methods for describing and reporting the clinical and histologic characteristics of cutaneous tissue samples from patients with hidradenitis suppurativa (HS) are not currently standardized, limiting clinicians’ and scientists’ ability to uniformly record, report, and communicate about the characteristics of tissue used in translational experiments. A recently published consensus statement outlined morphological definitions of typical HS lesions, but no consensus has been reached regarding clinical characterization and examination of HS tissue samples. In this study, we aimed to establish a protocol for reporting histopathologic and clinical characteristics of HS tissue specimens. This study was conducted from May 2023 to August 2023. Experts in clinical care, dermatopathology, and translational research were recruited, and a modified Delphi technique was used to develop a protocol for histologic reporting and clinical characterization of submitted tissue specimens from patients with HS. A total of 27 experts participated (14 dermatologists, 3 fellowship-trained dermatopathologists, 3 plastic surgeons, 3 general surgeons, and 4 research scientists) in creating and reviewing protocols for the clinical and histopathological examination of HS tissue specimens. The protocols were formatted as a synoptic report and will help to consistently classify specimens in biobanks on the basis of histologic features and more accurately report and select samples used in translational research projects.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Medicine
Publisher:	Elsevier
ISSN:	0022-202X
Date of First Compliant Deposit:	23 June 2024
Date of Acceptance:	26 February 2024
Last Modified:	11 Jul 2024 20:49
URI:	https://orca.cardiff.ac.uk/id/eprint/170073

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