Design of novel triply periodic minimal surface (TPMS) bone scaffold with multi-functional pores: lower stress shielding and higher mass transport capacity

Jiang, Jian, Huo, Yi, Peng, Xing, Wu, Chingwei, Zhu, Hanxing ORCID: https://orcid.org/0000-0002-3209-6831 and Lyu, Yongtao 2024. Design of novel triply periodic minimal surface (TPMS) bone scaffold with multi-functional pores: lower stress shielding and higher mass transport capacity. Frontiers in Bioengineering and Biotechnology 12 , 1401899. 10.3389/fbioe.2024.1401899

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Abstract

Background: The bone repair requires the bone scaffolds to meet various mechanical and biological requirements, which makes the design of bone scaffolds a challenging problem. Novel triply periodic minimal surface (TPMS)-based bone scaffolds were designed in this study to improve the mechanical and biological performances simultaneously. Methods: The novel bone scaffolds were designed by adding optimization-guided multi-functional pores to the original scaffolds, and finite element (FE) method was used to evaluate the performances of the novel scaffolds. In addition, the novel scaffolds were fabricated by additive manufacturing (AM) and mechanical experiments were performed to evaluate the performances. Results: The FE results demonstrated the improvement in performance: the elastic modulus reduced from 5.01 GPa (original scaffold) to 2.30 GPa (novel designed scaffold), resulting in lower stress shielding; the permeability increased from 8.58 × 10−9 m2 (original scaffold) to 5.14 × 10−8 m2 (novel designed scaffold), resulting in higher mass transport capacity. Conclusion: In summary, the novel TPMS scaffolds with multi-functional pores simultaneously improve the mechanical and biological performances, making them ideal candidates for bone repair. Furthermore, the novel scaffolds expanded the design domain of TPMS-based bone scaffolds, providing a promising new method for the design of high-performance bone scaffolds.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Engineering
Publisher:	Frontiers Media
ISSN:	2296-4185
Date of First Compliant Deposit:	26 June 2024
Date of Acceptance:	7 June 2024
Last Modified:	09 Jul 2024 09:54
URI:	https://orca.cardiff.ac.uk/id/eprint/170115

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