Positive selection analysis of Cyt proteins from Bacillus thuringiensis: a conservative trend driven by negative (purifying) selection.

Palma, Leopoldo, Sauka, Diego Herman, Berry, Colin ORCID: https://orcid.org/0000-0002-9943-548X and Peralta, Cecilia 2024. Positive selection analysis of Cyt proteins from Bacillus thuringiensis: a conservative trend driven by negative (purifying) selection. Toxicon 247 , 107853. 10.1016/j.toxicon.2024.107853 Item availability restricted.

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Abstract

Bacillus thuringiensis is a Gram-positive entomopathogenic bacterium that produces different pesticidal proteins: vegetative insecticidal proteins (Vpb1/Vpa2, Vip3, and Vpb4) during vegetative growth, which are secreted to the culture medium, and δ–endotoxins (Cry and Cyt) during sporulation, which accumulate into parasporal crystals. Cyt proteins are the smaller subset of δ–endotoxins targeting Diptera species. While Cry and Vip3 proteins undergo positive selection, our analysis suggests that Cyt proteins evolve following a conservative trend driven negative (purifying) selection.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Biosciences
Publisher:	Elsevier
ISSN:	0041-0101
Date of First Compliant Deposit:	11 July 2024
Date of Acceptance:	4 July 2024
Last Modified:	09 Nov 2024 06:45
URI:	https://orca.cardiff.ac.uk/id/eprint/170511

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