Health-exposure modeling and the ecological fallacy

Wakefield, J and Shaddick, G ORCID: https://orcid.org/0000-0002-4117-4264 2006. Health-exposure modeling and the ecological fallacy. Biostatistics 7 (3) , pp. 438-455. 10.1093/biostatistics/kxj017

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Abstract

Recently, there has been an increased interest in modeling the association between aggregate disease counts and environmental exposures measured, for example via air pollution monitors, at point locations. This paper has two aims: first, we develop a model for such data in order to avoid ecological bias; second, we illustrate that modeling the exposure surface and estimating exposures may lead to bias in estimation of health effects. Design issues are also briefly considered, in particular the loss of information in moving from individual to ecological data, and the at-risk populations to consider in relation to the pollution monitor locations. The approach is investigated initially through simulations, and is then applied to a study of the association between mortality in those over 65 in the year 2000 and the previous year's SO2, in London. We conclude that the use of the proposed model can provide valid inference, but the use of estimated exposures should be carried out with great caution.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	?? VCO ??
Publisher:	Oxford University Press
ISSN:	1465-4644
Date of Acceptance:	10 January 2006
Last Modified:	02 Aug 2024 15:15
URI:	https://orca.cardiff.ac.uk/id/eprint/170800

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