Ng, Vincent, Ying Li, Cheuk, Cornes, Paul and Votruba, Marcela  ORCID: https://orcid.org/0000-0002-7680-9135
2024.
The landscape of clinical trials research in inherited ophthalmic disease.
Ophthalmic Genetics
45
(6)
, pp. 558-565.
10.1080/13816810.2024.2378013
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Abstract
Objective To describe the current status of clinical trials of genetic eye diseases with identified molecular targets for future areas of research. Method Data analysis of the clinical trials database on clinicaltrials.gov with keywords for eight common, genetically tractable inherited eye diseases and their common molecular targets was performed during the period from 20 March 2021 to 31 December 2023. Results Two hundred and eighty-eight trials involving our keywords have been identified, excluding 25 (8.7%) trials which were unknown (verification expired with no update), 14 (4.9%) trials which were terminated early and 6(2.1%) trials which were withdrawn. In total there were 243 (84.4%) trials included. Out of the 243 trials, 120 trials were completed, 76 trials were active and still open to recruitment and 44 trials were active without any more recruitment on the way. There were only 32 (13.2%) trials with posted results. Conclusions A low percentage of results were posted for completed trials. However, current and future clinical trials in the genetic eye diseases with molecular targets identified, have a promising future. The results of these trials will enhance and allow a better understanding of the potential to develop treatments for these conditions.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Optometry and Vision Sciences |
| Publisher: | Taylor and Francis Group |
| ISSN: | 1381-6810 |
| Date of First Compliant Deposit: | 22 August 2024 |
| Date of Acceptance: | 4 July 2024 |
| Last Modified: | 24 Jul 2025 01:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/171271 |
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