Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast

Schmid, K. W., Ellis, I. O., Gee, Julia Margaret Wendy ORCID: https://orcid.org/0000-0001-6483-2015, Darke, Barbara M., Lees, W. E., Kay, John, Cryer, Anthony, Stark, J. M., Hittmair, A., Öfner, D., Dünser, M., Margreiter, R., Daxenbichler, G., Nicholson, Robert Ian, Bier, B., Böcker, W. and Jasani, Bharat 1993. Presence and possible significance of immunocytochemically demonstrable metallothionein over-expression in primary invasive ductal carcinoma of the breast. Virchovs Archiv 422 (2) , pp. 153-159. 10.1007/BF01607167

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Abstract

Metallothioneins (MTs) are ubiquitous low-molecular-weight proteins with a high affinity for heavy metal ions such as zinc, copper and cadmium. MT over-expression has been associated with resistance against anticancer drugs. In the present study we investigated 86 cases (45 cases of tumour category pT1 and 41 of category pT2) of routinely fixed and paraffin-embedded primary breast carcinomas immunohistochemically with a monoclonal antibody to an epitope of MT shared by its I and II isoforms. Immunohistochemically demonstrated MT over-expression was found in the invasive components of 7 of 32 pT1 and 17 of 28 pT2 invasive ductal carcinomas, whereas all 26 invasive lobular carcinomas gave weak or negative results. Fourteen of 17 pT2 and 2 of 7 pT1 invasive ductal carcinomas with MT over-expression developed metastases during follow-up with poor prognostic outcome.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy Medicine
Subjects:	R Medicine > RC Internal medicine > RC0254 Neoplasms. Tumors. Oncology (including Cancer) R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	Metallothionein - Breast cancer - Oestrogen receptors - Progesterone receptors - Immunohistochemistry
Additional Information:	Parts of this work were presented at the Autumn Meeting of the German Pathology Society, Mainz, October 1990 (Schmid et al. 1990), and the Meeting of the Pathology Society of Great Britain and Ireland, Manchester, July 1992 (Reid et al. 1992).
Publisher:	Springer
ISSN:	0945-6317
Last Modified:	04 Dec 2024 23:34
URI:	https://orca.cardiff.ac.uk/id/eprint/17129

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