Physicochemical and biological properties of dental materials and formulations with silica nanoparticles: A narrative review

Pavanello, Larissa, Cortês, Iago Torres, de Carvalho, Rafaela Durrer Parolina, Picolo, Mayara Zaghi Dal, Cavalli, Vanessa, Silva, Larissa Tavares Sampaio, Boaro, Letícia Cristina Cidreira, Prokopovich, Polina ORCID: https://orcid.org/0000-0002-5700-9570 and Cogo-Müller, Karina 2024. Physicochemical and biological properties of dental materials and formulations with silica nanoparticles: A narrative review. Dental Materials 40 (11) , pp. 1729-1741. 10.1016/j.dental.2024.07.028

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Abstract

Objective Silica nanoparticles (SNPs) have been extensively studied and used in different dental applications to promote improved physicochemical properties, high substance loading efficiency, in addition to sustained delivery of substances for therapeutic or preventive purposes. Therefore, this study aimed to review the SNPs applications in nanomaterials and nanoformulations in dentistry, discussing their effect on physicochemical properties, biocompatibility and ability to nanocarry bioactive substances. Data resources Literature searches were conducted on PubMed, Web of Science, and Scopus databases to identify studies examining the physicochemical and biological properties of dental materials and formulations containing SNPs. Data extraction was performed by one reviewer and verified by another Study selection A total of 50 were reviewed. In vitro studies reveal that SNPs improved the general properties of dental materials and formulations, such as microhardness, fracture toughness, flexural strength, elastic modulus and surface roughness, in addition to acting as efficient nanocarriers of substances, such as antimicrobial, osteogenic and remineralizing substances, and showed biocompatibility Conclusions SNPs are biocompatible, improve properties of dental materials and serve as effective carriers for bioactive substances Clinical significance Overall, SNPs are a promising drug delivery system that can improve dental materials biological and physicochemical and aesthetic properties, increasing their longevity and clinical performance. However, more studies are needed to elucidate SNPs short- and long-term effects in the oral cavity, mainly on in vivo and clinical studies, to prove their effectiveness and safety.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Pharmacy
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by-nc-nd/4.0/, Start Date: 2024-07-25
Publisher:	Elsevier
ISSN:	0109-5641
Date of First Compliant Deposit:	12 August 2024
Date of Acceptance:	25 July 2024
Last Modified:	10 Mar 2025 10:21
URI:	https://orca.cardiff.ac.uk/id/eprint/171315

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