COVID-19 outbreak: pathogenesis, current therapies, and potentials for future management

Hossain, Md. Farhad, Hasana, Sharifa, Mamun, Abdullah Al, Uddin, Md. Sahab, Wahed, Mir Imam Ibne, Sarker, Sabarni, Behl, Tapan, Ullah, Irfan, Begum, Yesmin, Bulbul, Israt Jahan, Amran, Md. Shah, Rahman, Md. Habibur, Bin-Jumah, May N., Alkahtani, Saad, Mousa, Shaker A., Aleya, Lotfi and Abdel-Daim, Mohamed M. 2020. COVID-19 outbreak: pathogenesis, current therapies, and potentials for future management. Frontiers in Pharmacology 11 , 563478. 10.3389/fphar.2020.563478

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Abstract

At the end of 2019, a novel coronavirus (CoV) was found at the seafood market of Hubei province in Wuhan, China, and this virus was officially named coronavirus diseases 2019 (COVID-19) by World Health Organization (WHO). COVID-19 is mainly characterized by severe acute respiratory syndrome coronavirus-2 (SARS-CoV2) and creates public health concerns as well as significant threats to the economy around the world. Unfortunately, the pathogenesis of COVID-19 is unclear and there is no effective treatment of this newly life-threatening and devastating virus. Therefore, it is crucial to search for alternative methods that alleviate or inhibit the spread of COVID-19. In this review, we try to find out the etiology, epidemiology, symptoms as well as transmissions of this novel virus. We also summarize therapeutic interventions and suggest antiviral treatments, immune-enhancing candidates, general supplements, and CoV specific treatments that control replication and reproduction of SARS-CoV and Middle East respiratory syndrome coronavirus (MERS-CoV).

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Frontiers Media
ISSN:	1663-9812
Date of First Compliant Deposit:	2 October 2024
Date of Acceptance:	15 September 2020
Last Modified:	02 Oct 2024 08:40
URI:	https://orca.cardiff.ac.uk/id/eprint/171616

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