Challenges of using routinely collected healthcare system data in randomised trials

Twine, Christopher P. ORCID: https://orcid.org/0000-0003-0385-5760, Ahmed, Haroon ORCID: https://orcid.org/0000-0002-0634-8548, Lugg-Widger, Fiona V. ORCID: https://orcid.org/0000-0003-0029-9703, Waldron, Cherry-Ann ORCID: https://orcid.org/0000-0001-8465-2492, Bown, Matt J. and Sydes, Matthew R. 2024. Challenges of using routinely collected healthcare system data in randomised trials. European Journal of Vascular and Endovascular Surgery 68 (3) , pp. 416-417. 10.1016/j.ejvs.2024.05.010 Item availability restricted.

PDF - Accepted Post-Print Version Restricted to Repository staff only until 10 May 2025 due to copyright restrictions. Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (194kB)

Abstract

There is increasing interest in using individually linked, routinely collected healthcare systems data for randomised controlled trials (RCTs). These data enabled trials aim to reduce site and participant burden and increase efficiency of trial delivery.1 Routinely collected data have successfully been used in large big data retrospective studies for years,2 and new methodology such as target trial emulation has enabled researchers to reduce the bias inherent to retrospective data.3 This still cannot replace the traditional randomised trial design, but a hybrid approach potentially builds on the strengths of both designs.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Centre for Trials Research (CNTRR)
Publisher:	Elsevier
ISSN:	1078-5884
Date of First Compliant Deposit:	30 August 2024
Date of Acceptance:	10 May 2024
Last Modified:	07 Nov 2024 21:15
URI:	https://orca.cardiff.ac.uk/id/eprint/171680

Actions (repository staff only)

Edit Item