Following hip fracture, hospital organizational factors associated with prescription of anti-osteoporosis medication on discharge, to address imminent refracture risk: a record-linkage study

Patel, Rita, Judge, Andrew, Johansen, Antony, Javaid, Muhammad K., Griffin, Xavier L., Chesser, Tim, Griffin, Jill, Marques, Elsa M. R., Gregson, Celia L., Johansen, Antony, Chesser, Tim, Javaid, Muhammad K., Griffin, Xavier L., Griffin, Jill, Marques, Elsa M. R., Ben-Shlomo, Yoav, Drew, Sarah, Judge, Andrew, Patel, Rita, Whale, Katie, Ben-Shlomo, Yoav and Gregson, Celia L. 2024. Following hip fracture, hospital organizational factors associated with prescription of anti-osteoporosis medication on discharge, to address imminent refracture risk: a record-linkage study. Journal of Bone and Mineral Research (JBMR) 39 (8) , pp. 1071-1082. 10.1093/jbmr/zjae100

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Abstract

Patients who sustain a hip fracture are known to be at imminent refracture risk. Their complex multidisciplinary rehabilitation needs to include falls prevention and anti-osteoporosis medication (AOM) to prevent such fractures. This study aimed to determine which hospital-level organizational factors predict prescription of post-hip fracture AOM and refracture risk. A cohort of 178 757 patients aged ≥60 yr who sustained a hip fracture in England and Wales (2016-2019) was examined and followed for 1 yr. Patient-level hospital admission datasets from 172 hospitals, the National Hip Fracture Database, and mortality data were linked to 71 metrics extracted from 18 hospital-level organizational reports. Multilevel models determined organizational factors, independent of patient case-mix, associated with (1) AOM prescription and (2) refracture (by ICD10 coding). Patients were mean (SD) 82.7 (8.6) yr old, 71% female, with 18% admitted from care homes. Overall, 101 735 (57%) were prescribed AOM during admission, while 50 354 (28%) died during 1-yr follow-up, 12 240 (7%) refractured. Twelve organizational factors were associated with AOM prescription, for example, orthogeriatrician-led care compared to traditional care models (odds ratio [OR] 4.65 [95% CI, 2.25–9.59]); AOM was 9% (95% CI, 6%–13%) more likely to be prescribed in hospitals providing routine bone health assessment to all patients. Refracture occurred at median 126 d (IQR 59–234). Eight organizational factors were associated with refracture risk; hospitals providing orthogeriatrician assessment to all patients within 72 h of admission had an 18% (95% CI, 2%–31%) lower refracture risk, weekend physiotherapy provision had an 8% (95% CI, 3%–14%) lower risk, and where occupational therapists attended clinical governance meetings, a 7% (95% CI, 2%–12%) lower risk. Delays initiating post-discharge community rehabilitation were associated with a 15% (95% CI, 3%–29%) greater refracture risk. These novel, national findings highlight the importance of orthogeriatrician, physiotherapist, and occupational therapist involvement in secondary fracture prevention post hip fracture; notably, fracture risk reductions were seen within 12 mo of hip fracture.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	American Society for Bone and Mineral Research
ISSN:	0884-0431
Date of First Compliant Deposit:	10 September 2024
Date of Acceptance:	9 July 2024
Last Modified:	09 Oct 2024 12:43
URI:	https://orca.cardiff.ac.uk/id/eprint/171967

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