A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19

Sandoe, Jonathan A. T., Grozeva, Detelina ORCID: https://orcid.org/0000-0003-3239-8415, Albur, Mahableshwar, Bond, Stuart E., Brookes-Howell, Lucy ORCID: https://orcid.org/0000-0002-8263-7130, Dark, Paul, Euden, Joanne ORCID: https://orcid.org/0000-0002-2844-6878, Hamilton, Ryan, Hellyer, Thomas P., Henley, Josie, Hopkins, Susan, Howard, Philip, Howdon, Daniel, Knox-Macaulay, Chikezie, Llewelyn, Martin J., Maboshe, Wakunyambo, McCullagh, Iain J., Ogden, Margaret, Parsons, Helena K., Partridge, David G., Powell, Neil, Prestwich, Graham, Shaw, Dominick, Shinkins, Bethany, Szakmany, Tamas ORCID: https://orcid.org/0000-0003-3632-8844, Thomas-Jones, Emma ORCID: https://orcid.org/0000-0001-7716-2786, Todd, Stacy, West, Robert M., Carrol, Enitan D. and Pallmann, Philip ORCID: https://orcid.org/0000-0001-8274-9696 2024. A retrospective propensity-score-matched cohort study of the impact of procalcitonin testing on antibiotic use in hospitalized patients during the first wave of COVID-19. Journal of Antimicrobial Chemotherapy , dkae246. 10.1093/jac/dkae246

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Abstract

Background Procalcitonin (PCT) is a blood marker used to help diagnose bacterial infections and guide antibiotic treatment. PCT testing was widely used/adopted during the COVID-19 pandemic in the UK. Objectives Primary: to measure the difference in length of early (during first 7 days) antibiotic prescribing between patients with COVID-19 who did/did not have baseline PCT testing during the first wave of the pandemic. Secondary: to measure differences in length of hospital/ICU stay, mortality, total days of antibiotic prescribing and resistant bacterial infections between these groups. Methods Multi-centre, retrospective, observational, cohort study using patient-level clinical data from acute hospital Trusts/Health Boards in England/Wales. Inclusion: patients ≥16 years, admitted to participating Trusts/Health Boards and with a confirmed positive COVID-19 test between 1 February 2020 and 30 June 2020. Results Data from 5960 patients were analysed: 1548 (26.0%) had a baseline PCT test and 4412 (74.0%) did not. Using propensity-score matching, baseline PCT testing was associated with an average reduction in early antibiotic prescribing of 0.43 days [95% confidence interval (CI): 0.22–0.64 days, P < 0.001) and of 0.72 days (95% CI: 0.06–1.38 days, P = 0.03] in total antibiotic prescribing. Baseline PCT testing was not associated with increased mortality or hospital/ICU length of stay or with the rate of antimicrobial-resistant secondary bacterial infections. Conclusions Baseline PCT testing appears to have been an effective antimicrobial stewardship tool early in the pandemic: it reduced antibiotic prescribing without evidence of harm. Our study highlights the need for embedded, rapid evaluations of infection diagnostics in the National Health Service so that even in challenging circumstances, introduction into clinical practice is supported by evidence for clinical utility.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Medicine Centre for Trials Research (CNTRR) Social Sciences (Includes Criminology and Education)
Publisher:	Oxford University Press
ISSN:	0305-7453
Date of First Compliant Deposit:	13 September 2024
Date of Acceptance:	14 June 2024
Last Modified:	08 Nov 2024 03:30
URI:	https://orca.cardiff.ac.uk/id/eprint/172104

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