A literature review on pharmacological aspects, docking studies, and synthetic approaches of quinazoline and quinazolinone derivatives

Ghoneim, Mohammed M., Abdelgawad, Mohamed A., Elkanzi, Nadia A. A., Parambi, Della Grace Thomas, Alsalahat, Izzeddin, Farouk, Amr and Bakr, Rania B. 2024. A literature review on pharmacological aspects, docking studies, and synthetic approaches of quinazoline and quinazolinone derivatives. Archiv der Pharmazie 357 (8) , 2400057. 10.1002/ardp.202400057 Item availability restricted.

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Abstract

Quinazoline and quinazolinone derivatives piqued medicinal chemistry interest in developing novel drug candidates owing to their pharmacological potential. They are important chemicals for the synthesis of a variety of physiologically significant and pharmacologically useful molecules. Quinazoline and quinazolinone derivatives have anticancer, anti-inflammatory, antidiabetic, anticonvulsant, antiviral, and antimicrobial potential. The increased understanding of quinazoline and quinazolinone derivatives in biological activities provides opportunities for new medicinal products. The present review focuses on novel advances in the synthesis of these important scaffolds and other medicinal aspects involving drug design, structure–activity relationship, and action mechanisms of quinazoline and quinazolinone derivatives to help in the development of new quinazoline and quinazolinone derivatives.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Wiley-VCH Verlag
ISSN:	0365-6233
Date of First Compliant Deposit:	25 September 2024
Date of Acceptance:	28 April 2024
Last Modified:	08 Nov 2024 00:00
URI:	https://orca.cardiff.ac.uk/id/eprint/172371

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