Persistent child and adolescent anxiety predicts development of psychotic disorders via elevated inflammation

Westacott, Laura Jayne 2022. Persistent child and adolescent anxiety predicts development of psychotic disorders via elevated inflammation. Biological Psychiatry 92 (4) , e19-e20. 10.1016/j.biopsych.2022.06.009

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Abstract

Psychotic disorders (PDs) are a common group of conditions that include schizophrenia, schizoaffective disorder, and brief psychotic episodes. These disorders have a varied and complex etiology comprising genetic and environmental risk factors. PDs such as schizophrenia often have a prodromal stage during adolescence, and subsequent diagnosis hinges on symptoms presenting over the course of several years, but the manifestation of these symptoms is likely a consequence of brain changes in the years predating their onset. We may therefore find clues as to the antecedents of PDs by looking at late childhood and early adolescence. In the current issue of Biological Psychiatry, Morales-Muñoz et al. (1) examine the prospective association between persistent child and adolescent anxiety, inflammation, and adult psychosis, and their results hold important implications for novel therapeutic strategies for reducing psychosis risk by targeting childhood anxiety and/or inflammation.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine MRC Centre for Neuropsychiatric Genetics and Genomics (CNGG)
Publisher:	Elsevier
ISSN:	0006-3223
Date of First Compliant Deposit:	16 October 2024
Date of Acceptance:	9 June 2022
Last Modified:	15 Jan 2025 11:45
URI:	https://orca.cardiff.ac.uk/id/eprint/172915

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