Actovegin® cutting-edge sports medicine or 'Voodoo' remedy?

Lee, Paul, Kwan, Alan Shu Khen ORCID: https://orcid.org/0000-0003-4206-4435 and Nokes, Leonard Derek Martin ORCID: https://orcid.org/0000-0002-9504-8028 2011. Actovegin® cutting-edge sports medicine or 'Voodoo' remedy? Current Sports Medicine Reports 10 (4) , pp. 186-190. 10.1249/JSR.0b013e318223cd8a

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Abstract

Actovegin® is a deproteinized serum extract of bovine origin, and in recent years it has been used widely in treating sport injuries with many anecdotal reports of success. However, the use of Actovegin® in sport medicine has caused a substantial amount of controversy, especially concerning its supposed oxygen-enhancing capacity and an anecdotal belief that its use can increase an athlete's performance. In 2009, a sports physician was arrested with this 'performance-enhancing drug,' while an editorial in a sports medicine journal strongly questioned the evidence base for using this drug for acute muscle injury. There is also a report that suggested that Actovegin® might have induced anaphylactic shock in a cyclist. In this review, we have systematically examined the current evidence on Actovegin®. Its mechanism of action, clinical evidence, legal status with sports governing bodies, and its potential role in sport injuries will be discussed. Copyright © 2011 by the American College of Sports Medicine.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Engineering
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Uncontrolled Keywords:	EMTREE drug terms: actovegin; placebo EMTREE medical terms: anaphylactic shock; anaphylaxis; article; athletic performance; diabetic neuropathy; doping; drug mechanism; drug megadose; drug safety; fracture; human; medicolegal aspect; molecular mechanics; mouth ulcer; muscle injury; non insulin dependent diabetes mellitus; postpartum hemorrhage; skin ulcer; sport injury; sports medicine
Publisher:	Lippincott Williams & Wilkins
ISSN:	1537-890X
Last Modified:	18 Oct 2022 14:23
URI:	https://orca.cardiff.ac.uk/id/eprint/17297

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