Association of NTRK2 gene with suicidality: a meta-analysis

Ye, Wenzhu, Zhang, Ruo Su, Hosang, Georgina M., Fabbri, Chiara, King, Nicole, Strauss, John, Jones, Ian ORCID: https://orcid.org/0000-0001-5821-5889, Jones, Lisa, Breen, Gerome, Kennedy, James L., Vincent, John B. and Zai, Clement C. 2024. Association of NTRK2 gene with suicidality: a meta-analysis. Psychiatric Genetics 10.1097/ypg.0000000000000373 Item availability restricted.

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Abstract

Background Previous studies have shown that genes in brain development pathways may have important roles in affecting risk of suicidal behaviors, with our previous meta-analysis supporting a role of the brain-derived neurotrophic factor (BDNF) gene. NTRK2 is a gene that encodes the neurotrophic receptor tyrosine kinase 2, which is a receptor for BDNF. In the current study, we aim to examine the potential association between NTRK2 single nucleotide polymorphism (SNPs) and suicidal ideation/behaviors. Methods We first conducted a literature search using keywords like ‘NTRK2’, ‘TRKB’, and ‘suicid*’ to identify papers on NTRK2 SNPs and suicidal ideation/behaviors. In addition, we have individual-level genotype data for all the identified SNPs in literature search. We used the R meta package to perform meta-analyses on both the genotype count and the allele count data. Moreover, we performed meta-analyses on specific haplotypes within each haplotype block. Main results Following our literature search and meta-analyses on 20 NTRK2 SNPs across up to 8467 samples, we found three SNPs, rs10868235 [N = 5,318, odds ratio (OR) = 1.34, P = 0.02], rs1867283 (N = 5,134, OR = 0.73, P = 0.04), and rs1147198 (N = 5,132, OR = 1.36, P = 0.03) to be nominally associated with suicidal attempts. Those three findings, however, did not survive multiple-testing corrections. Also, none of the haplotype blocks showed significant involvement in suicidality. Conclusion Our results suggest that the NTRK2 gene may not have a major role in suicidality. Future efforts, however, should explore gene–gene interaction and pathway analyses.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Medicine
Publisher:	Lippincott, Williams & Wilkins
ISSN:	0955-8829
Date of First Compliant Deposit:	21 November 2024
Last Modified:	21 Nov 2024 10:15
URI:	https://orca.cardiff.ac.uk/id/eprint/172980

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