Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH

Bermejo-Velasco, Daniel, Nawale, Ganesh N., Oommen, Oommen P. ORCID: https://orcid.org/0000-0003-2768-0133, Hilborn, Jons and Varghese, Oommen P. 2018. Thiazolidine chemistry revisited: a fast, efficient and stable click-type reaction at physiological pH. Chemical Communications 54 (88) , pp. 12507-12510. 10.1039/c8cc05405c

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Abstract

We describe the fast reaction kinetics between 1,2-aminothiols and aldehydes. Under physiological conditions such a click-type reaction afforded a thiazolidine product that remains stable and did not require any catalyst. This type of bioorthogonal reaction offers enormous potential for the coupling of biomolecules in an efficient and biocompatible manner.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Royal Society of Chemistry
ISSN:	1359-7345
Last Modified:	21 Oct 2024 15:15
URI:	https://orca.cardiff.ac.uk/id/eprint/172984

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