An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels

Samanta, Sumanta, Rangasami, Vignesh K., Murugan, N. Arul, Parihar, Vijay Singh, Varghese, Oommen P. and Oommen, Oommen P. ORCID: https://orcid.org/0000-0003-2768-0133 2021. An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels. Polymer Chemistry 12 (20) , pp. 2987-2991. 10.1039/d1py00013f

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Abstract

We present here a new insight into the chemical reactivity and bioactivity of dopamine (DA) and gallic acid (GA) and their hyaluronic acid (HA) conjugates. Our data suggest that HA–GA scaffolds are superior to HA–DA, with higher oxidation kinetics, improved tissue adhesive properties, and radical scavenging ability with a lower pro-inflammatory response.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Publisher:	Royal Society of Chemistry
ISSN:	1759-9962
Last Modified:	04 Nov 2024 16:15
URI:	https://orca.cardiff.ac.uk/id/eprint/173012

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