Mechanisms of action of microbicides commonly used in infection prevention and control

Gerba, Charles P., Boone, Stephanie, Nims, Raymond W., Maillard, Jean-Yves ORCID: https://orcid.org/0000-0002-8617-9288, Sattar, Syed A., Rubino, Joseph R., McKinney, Julie and Ijaz, M. Khalid 2024. Mechanisms of action of microbicides commonly used in infection prevention and control. Microbiology and Molecular Biology Reviews 88 (3) , e00205-22.. 10.1128/mmbr.00205-22

Full text not available from this repository.

Abstract

SUMMARY Understanding how commonly used chemical microbicides affect pathogenic microorganisms is important for formulation of microbicides. This review focuses on the mechanism(s) of action of chemical microbicides commonly used in infection prevention and control. Contrary to the typical site-specific mode of action of antibiotics, microbicides often act via multiple targets, causing rapid and irreversible damage to microbes. In the case of viruses, the envelope or protein capsid is usually the primary structural target, resulting in loss of envelope integrity or denaturation of proteins in the capsid, causing loss of the receptor-binding domain for host cell receptors, and/or breakdown of other viral proteins or nucleic acids. However, for certain virucidal microbicides, the nucleic acid may be a significant site of action. The region of primary damage to the protein or nucleic acid is site-specific and may vary with the virus type. Due to their greater complexity and metabolism, bacteria and fungi offer more targets. The rapid and irreversible damage to microbes may result from solubilization of lipid components and denaturation of enzymes involved in the transport of nutrients. Formulation of microbicidal actives that attack multiple sites on microbes, or control of the pH, addition of preservatives or potentiators, and so on, can increase the spectrum of action against pathogens and reduce both the concentrations and times needed to achieve microbicidal activity against the target pathogens.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Pharmacy
Additional Information:	License information from Publisher: LICENSE 1: URL: https://doi.org/10.1128/ASMCopyrightv2, Start Date: 2024-09-26
Publisher:	American Society for Microbiology
ISSN:	1092-2172
Last Modified:	18 Oct 2024 09:31
URI:	https://orca.cardiff.ac.uk/id/eprint/173114

Actions (repository staff only)

Edit Item