Becerra-Ruiz, Martin, Winterson, Bethan, Pérez, Edwin and Wirth, Thomas  ORCID: https://orcid.org/0000-0002-8990-0667
2025.
Hydrofluoroether synthesis through one‐pot anodic iodoalkoxylation of alkenes.
Advanced Synthesis & Catalysis
367
(8)
, e202401108.
10.1002/adsc.202401108
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License URL: http://creativecommons.org/licenses/by/4.0/
License Start date: 14 October 2024
Official URL: https://doi.org/10.1002/adsc.202401108
Abstract
The incorporation of carbon‐fluorine bonds can profoundly influence the chemical and physical properties of drugs, agrochemicals, and materials. Different methods allow the installation of CF<sub>3</sub>, CF<sub>2</sub>H units and C–F bonds including trifluoro‐ and difluoromethoxylations, reflecting the limited diversity of reactions available to synthetic chemists. We introduce the trifluoroethoxy group through an electro‐oxidative iodination of alkenes as a versatile substituent for fluorine chemists. An iodoarene serves as an unusual iodine source facilitating the 1,2‐iodoalkoxylation of a broad range of industrially relevant aliphatic alkenes in high yields (31–98%) showing high Markovnikov regioselectivity.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Chemistry |
| Publisher: | Wiley |
| ISSN: | 1615-4150 |
| Date of First Compliant Deposit: | 25 October 2024 |
| Date of Acceptance: | 14 October 2024 |
| Last Modified: | 05 Jun 2025 09:54 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/173338 |
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