Hydrofluoroether synthesis through one‐pot anodic iodoalkoxylation of alkenes

Becerra-Ruiz, Martin, Winterson, Bethan, Pérez, Edwin and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2024. Hydrofluoroether synthesis through one‐pot anodic iodoalkoxylation of alkenes. Advanced Synthesis & Catalysis 10.1002/adsc.202401108

PDF - Published Version Download (1MB)

Abstract

The incorporation of carbon‐fluorine bonds can profoundly influence the chemical and physical properties of drugs, agrochemicals, and materials. Different methods allow the installation of CF₃, CF₂H units and C–F bonds including trifluoro‐ and difluoromethoxylations, reflecting the limited diversity of reactions available to synthetic chemists. We introduce the trifluoroethoxy group through an electro‐oxidative iodination of alkenes as a versatile substituent for fluorine chemists. An iodoarene serves as an unusual iodine source facilitating the 1,2‐iodoalkoxylation of a broad range of industrially relevant aliphatic alkenes in high yields (31–98%) showing high Markovnikov regioselectivity.

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Chemistry
Additional Information:	License information from Publisher: LICENSE 1: URL: http://onlinelibrary.wiley.com/termsAndConditions#vor, Start Date: 2024-10-14
Publisher:	Wiley
ISSN:	1615-4150
Date of First Compliant Deposit:	25 October 2024
Date of Acceptance:	14 October 2024
Last Modified:	25 Oct 2024 09:30
URI:	https://orca.cardiff.ac.uk/id/eprint/173338

Actions (repository staff only)

Edit Item