Hydrofluoroether synthesis through one‐pot anodic iodoalkoxylation of alkenes

Becerra-Ruiz, Martin, Winterson, Bethan, Pérez, Edwin and Wirth, Thomas ORCID: https://orcid.org/0000-0002-8990-0667 2024. Hydrofluoroether synthesis through one‐pot anodic iodoalkoxylation of alkenes. Advanced Synthesis & Catalysis 10.1002/adsc.202401108

PDF - Published Version Available under License Creative Commons Attribution. Download (1MB)

Abstract

The incorporation of carbon‐fluorine bonds can profoundly influence the chemical and physical properties of drugs, agrochemicals, and materials. Different methods allow the installation of CF₃, CF₂H units and C–F bonds including trifluoro‐ and difluoromethoxylations, reflecting the limited diversity of reactions available to synthetic chemists. We introduce the trifluoroethoxy group through an electro‐oxidative iodination of alkenes as a versatile substituent for fluorine chemists. An iodoarene serves as an unusual iodine source facilitating the 1,2‐iodoalkoxylation of a broad range of industrially relevant aliphatic alkenes in high yields (31–98%) showing high Markovnikov regioselectivity.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Chemistry
Additional Information:	License information from Publisher: LICENSE 1: URL: http://onlinelibrary.wiley.com/termsAndConditions#vor, Start Date: 2024-10-14
Publisher:	Wiley
ISSN:	1615-4150
Date of First Compliant Deposit:	25 October 2024
Date of Acceptance:	14 October 2024
Last Modified:	24 Feb 2025 12:20
URI:	https://orca.cardiff.ac.uk/id/eprint/173338

Actions (repository staff only)

Edit Item