Williams, Kerry, Lada, Georgia, Reynolds, Nick J., Mcelhone, Kathleen, Evans, Ian, Warren, Richard B., Walton, Shernaz, Hughes, Olivia, Bewley, Anthony, Mason, Kayleigh and Kleyn, C. Elise
2025.
Risk of suicide and suicidality in patients with moderate to severe psoriasis: results from the British Association of Dermatologists Biologic and Immunomodulators Register (BADBIR).
Clinical and Experimental Dermatology
50
(4)
, pp. 804-811.
10.1093/ced/llae449
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Abstract
Background Psoriasis is associated with poor mental health and reduced quality of life. Although the high risk for depression in patients with psoriasis is well-established, their suicidality risk is uncertain. Previous studies provide contrasting results and have not included patients with clinically-confirmed severe disease. Objectives Our aim was to determine risk of suicide among patients with moderate to severe psoriasis compared with the general population, and investigate if psychiatric comorbidity or history of suicidality increases future suicidality risk in psoriasis. We further estimated the incidence of suicidal and self-injurious behaviours in patients. Methods Analysis was performed using the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR). As controls, general population mortality and suicide data were used. Results There were 9 suicides in BADBIR. The incidence rate of suicide was 12.5 per 100,000 person-years (95% CI 6.53, 24.11) in BADBIR versus 11.0 per 100,000 person-years (95% CI 10.7, 11.3) in the general population in England and Wales. Among patients, psychiatric comorbidity or past suicidality was associated with higher risk for suicidal ideation, suicide attempts and self-injurious behaviours. Conclusions Suicide rates among patients with moderate to severe psoriasis were not significantly higher compared with the general population. Suicide is a rare event and our results are limited by the uncertainty in the estimate reliability. However, considering the high depression prevalence in psoriasis, our findings support the need for prompt assessment of patients for psychiatric comorbidities and suicidality history. Further research is required on suicidal behaviours and the role of psoriasis severity.
| Item Type: | Article |
|---|---|
| Date Type: | Publication |
| Status: | Published |
| Schools: | Schools > Psychology |
| Publisher: | Oxford University Press |
| ISSN: | 0307-6938 |
| Funders: | UKRI/Wellcome |
| Date of First Compliant Deposit: | 25 October 2024 |
| Date of Acceptance: | 18 October 2024 |
| Last Modified: | 16 Apr 2025 12:45 |
| URI: | https://orca.cardiff.ac.uk/id/eprint/173405 |
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