Refractory fungal infection: Three case reports highlighting good practice

Barnes, Rosemary, Enoch, David A., Ingram, Wendy, Martin, Jessica, Clay, Jennifer, Tyler, Netta and White, P. Lewis 2024. Refractory fungal infection: Three case reports highlighting good practice. Medical Mycology Case Reports 46 , 100688. 10.1016/j.mmcr.2024.100688

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Abstract

Refractory invasive fungal infection is a significant clinical problem, with high morbidity, mortality and costs. The complex causes of refractory infection include breakthrough infection due to antifungal resistance (both innate and acquired), suboptimal therapy and impaired immune responses in critically ill or immunocompromised patients. This case series details three reports on the identification and management of refractory fungal infections, two cases of azole resistance and one case of resistant candidiasis, highlighting the importance of accurate diagnosis, monitoring, implementation of biomarkers (serological markers, PCR), antifungal susceptibility testing and antifungal stewardship to optimise management and minimise risks of emergence of drug resistance.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine Centre for Trials Research (CNTRR)
Additional Information:	License information from Publisher: LICENSE 1: URL: http://creativecommons.org/licenses/by-nc-nd/4.0/, Start Date: 2024-12-03
Publisher:	Elsevier / Elsevier: Creative Commons
ISSN:	2211-7539
Date of First Compliant Deposit:	15 January 2025
Date of Acceptance:	3 December 2024
Last Modified:	15 Jan 2025 14:31
URI:	https://orca.cardiff.ac.uk/id/eprint/174654

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