Relationship between age and plasma esterases

Abou‐Hatab, Khaled, O'Mahony, M. Sinead, Patel, Sarju and Woodhouse, Kenneth 2001. Relationship between age and plasma esterases. Age and Ageing 30 (1) , pp. 41-45. 10.1093/ageing/30.1.41

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Abstract

Introduction: the older population is the most medicated. Despite high drug usage, older people are generally excluded from the research underpinning new drug development. This means that drugs are prescribed to older people with very little understanding of how they are likely to metabolize them. More research is needed to investigate the possible effects of ageing on the biotransformation of drugs. We therefore undertook a cross‐sectional study examining the effect of age on the activities of benzoylcholinesterase, butyrylcholinesterase, acetylcholinesterase and aspirin esterase. Methods: we measured the activities of benzoylcholinesterase and butyrylcholinesterase in 70 healthy volunteers aged 18–85 years. We measured the activities of acetylcholinesterase and aspirin esterase in 43 healthy volunteers aged 18–85 years. We determined plasma activities of benzoylcholinesterase, butyrylcholinesterase, acetylcholinesterase and aspirin esterase spectrophotometrically. Results: we found no correlation between the activities of any of the enzymes measured and advancing age. Conclusion: age per se is not associated with reductions in the activities of esterase enzymes.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Medicine
Publisher:	Oxford University Press
ISSN:	0002-0729
Date of Acceptance:	30 August 2000
Last Modified:	03 Feb 2025 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/175587

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