Advances in role of CRAC channels in pathogenesis of pancreatitis

Peng, Shuang, Sun, Zelin, Liao, Die, Yang, Xiaolin and Ke, Lu 2024. Advances in role of CRAC channels in pathogenesis of pancreatitis. Chinese Journal of Pathophysiology 40 (12) , pp. 2351-2358. 10.3969/j.issn.1000-4718.2024.00.025

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Abstract

Calcium release-activated calcium (CRAC) channels are non-selective calcium ion channels widely expressed in non-excitatory cells. The opening of CRAC channels is a major mechanism for calcium influx in various pancreatic cells and immune cells. Therefore, CRAC channels are crucial for pancreatic exocrine calcium homeostasis and its various physiological functions. Numerous studies have shown that CRAC channels play a key role in the pathophysiology of acute and chronic pancreatitis. This article aims to review the latest findings on the pathogenesis of acute and chronic pancreatitis using CRAC channels and discuss the current applications and future directions of CRAC channel-based drug development.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	中国病理生理学会
ISSN:	1000-4718
Date of First Compliant Deposit:	31 January 2025
Date of Acceptance:	3 December 2024
Last Modified:	11 Nov 2025 13:45
URI:	https://orca.cardiff.ac.uk/id/eprint/175804

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