Molecular and cellular machinery of lymphatic metastasis in breast cancer

Cong, Binbin, Cao, Xiaoshan, Jiang, Wen ORCID: https://orcid.org/0000-0002-3283-1111 and Ye, Lin ORCID: https://orcid.org/0000-0002-0303-2409 2025. Molecular and cellular machinery of lymphatic metastasis in breast cancer. OncoTargets and Therapy 18 , pp. 199-209. 10.2147/OTT.S503272

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Abstract

Breast cancer is one of the most common malignant tumours in women worldwide. A primary route for breast cancer cells to disseminate is through regional lymphatic vessels and nodes. Cancer cell-induced lymphangiogenesis plays a crucial role in lymphatic metastasis and is associated with poor survival of breast cancer. Advances in molecular biology have led to the identification of biomarkers associated with lymphangiogenesis and lymphatic metastasis, including lymphatic vessel endothelial cell (LVEC) markers and tumour microenvironment markers, such as vascular endothelial growth factor receptor 3 (VEGFR3), podoplanin (PDPN), and lymphatic endothelial hyaluronan receptor-1 (LYVE1). LVEC molecular markers play a profound role in both the formation of new lymphatic vessels and the invasive expansion of primary tumour. Abnormal expression of LVEC markers may contribute to lymphatic vessel disease and/or metastasis of cancer cells through the lymphatic system. These molecular markers may present a potential for targeted therapies and precision diagnostics for managing lymphatic metastasis in breast cancer. This review aims to provide a comprehensive summary of the current understanding of the molecular and cellular machinery underlying lymphatic metastasis in breast cancer, with a particular focus on the lymphangiogenic markers and their role in the lymphatic dissemination.

Item Type:	Article
Status:	Published
Schools:	Schools > Medicine
Publisher:	Taylor and Francis Group
ISSN:	1178-6930
Date of First Compliant Deposit:	4 February 2025
Date of Acceptance:	23 January 2025
Last Modified:	19 Feb 2025 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/175929

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