An efficient and general synthesis of pyrroles

Sharland, Christopher Mark, Singkhonrat, Jirada ORCID: https://orcid.org/0000-0003-1841-3383, Najeebullah, Muhammad, Hayes, Simon, Knight, David William and Dunford, Damian Gordon 2011. An efficient and general synthesis of pyrroles. Tetrahedron Letters 52 (18) , pp. 2320-2323. 10.1016/j.tetlet.2011.02.085

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Abstract

We have discovered that a wide range of 3-alkynyl-hydroxyalkanamine derivatives undergo 5-endo-dig cyclisations when exposed to silver nitrate supported on silica gel. Subsequent in situ dehydration of the resulting and sometimes isolable hydroxy-dihydropyrroles leads to pyrroles in essentially quantitative yields using this recoverable and reusable heterogeneous catalyst.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Chemistry Cardiff Catalysis Institute (CCI)
Subjects:	Q Science > QD Chemistry
Uncontrolled Keywords:	Pyrroles; Synthesis; 5-endo-Dig; Silver(I); Heterogeneous catalyst
Publisher:	Elsevier
ISSN:	0040-4039
Last Modified:	06 May 2023 01:27
URI:	https://orca.cardiff.ac.uk/id/eprint/17624

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