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An efficient and general synthesis of pyrroles

Sharland, Christopher Mark, Singkhonrat, Jirada ORCID:, Najeebullah, Muhammad, Hayes, Simon, Knight, David William and Dunford, Damian Gordon 2011. An efficient and general synthesis of pyrroles. Tetrahedron Letters 52 (18) , pp. 2320-2323. 10.1016/j.tetlet.2011.02.085

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We have discovered that a wide range of 3-alkynyl-hydroxyalkanamine derivatives undergo 5-endo-dig cyclisations when exposed to silver nitrate supported on silica gel. Subsequent in situ dehydration of the resulting and sometimes isolable hydroxy-dihydropyrroles leads to pyrroles in essentially quantitative yields using this recoverable and reusable heterogeneous catalyst.

Item Type: Article
Date Type: Publication
Status: Published
Schools: Chemistry
Cardiff Catalysis Institute (CCI)
Subjects: Q Science > QD Chemistry
Uncontrolled Keywords: Pyrroles; Synthesis; 5-endo-Dig; Silver(I); Heterogeneous catalyst
Publisher: Elsevier
ISSN: 0040-4039
Last Modified: 06 May 2023 01:27

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