Efficacy of premedication with ketorolac on anaesthetic success of mental-incisive nerve blocks with symptomatic irreversible pulpitis: a randomised clinical trial

Venkateshbabu, Nagendrababu, Subbarao, Haritha Jamuna, Saumya, Parashar, Menon, Neeraj, Khandelwal, Priyal, Dummer, Paul M.H. ORCID: https://orcid.org/0000-0002-0726-7467, Velmurugan, Natanasabapathy and Nandini, Suresh 2025. Efficacy of premedication with ketorolac on anaesthetic success of mental-incisive nerve blocks with symptomatic irreversible pulpitis: a randomised clinical trial. Australian Endodontic Journal 10.1111/aej.12924 Item availability restricted.

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Abstract

This trial aimed to compare the success of mental-incisive nerve blocks (MINB) on mandibular premolars with symptomatic irreversible pulpitis (SIP) after oral premedication using 10 mg ketorolac or a placebo. One hundred and two patients were randomly divided into two groups. One hour prior to the administration of a MINB the patients were administered oral premedication's of either ketorolac or dextrose (placebo). The success of anaesthesia was verified by the absence of pain during the access cavity preparation or root canal instrumentation. Descriptive analysis was performed and one-way ANOVA was utilised for quantitative variables. Categorical data were analysed using chi-squared tests. Binary logistic regression was performed to assess the relationship among age, sex, type of premedication taken, preoperative pain score and tooth length to the pain outcome. The efficacy of MINB on mandibular premolars with SIP was not influenced significantly by the preoperative oral administration of ketorolac. Trial Registration: CTRI/2021/11/038115. [Abstract copyright: © 2025 Australian Society of Endodontology Inc.]

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Dentistry
Publisher:	Wiley
ISSN:	1329-1947
Date of First Compliant Deposit:	21 March 2025
Date of Acceptance:	20 January 2025
Last Modified:	21 Mar 2025 12:00
URI:	https://orca.cardiff.ac.uk/id/eprint/176511

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