Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013-2015

Genus, Tracey S. E., Bouvier, Catherine, Wong, Kwok F., Srirajaskanthan, Rajaventhan, Rous, Brian A., Talbot, Denis C., Valle, Juan W., Khan, Mohid, Pearce, Neil, Elshafie, Mona, Reed, Nicholas S., Morgan, Eileen, Deas, Andrew, White, Ceri, Huws, Dyfed and Ramage, John 2019. Impact of neuroendocrine morphology on cancer outcomes and stage at diagnosis: a UK nationwide cohort study 2013-2015. British Journal of Cancer 121 (11) , 966–972. 10.1038/s41416-019-0606-3

Full text not available from this repository.

Abstract

Background The diagnosis of neuroendocrine neoplasms (NENs) is often delayed. This first UK population-based epidemiological study of NENs compares outcomes with non-NENs to identify any inequalities. Methods Age-standardised incidence rate (ASR), 1-year overall survival, hazard ratios and standardised mortality rates (SMRs) were calculated for all malignant NENs diagnosed 2013–2015 from UK national Public Health records. Comparison with non-NENs assessed 1-year overall survival (1YS) and association between diagnosis at stage IV and morphology. Results A total of 15,222 NENs were identified, with an ASR (2013–2015 combined) of 8.6 per 100,000 (95% CI 8.5–8.7); 4.6 per 100 000 (95% CI, 4.5–4.7) for gastro-entero-pancreatic (GEP) NENs. The 1YS was 75% (95% CI, 73.9–75.4) varying significantly by sex. Site and morphology were prognostic. NENs (predominantly small cell carcinomas) in the oesophagus, bladder, prostate, and female reproductive organs had a poorer outcome and were three times more likely to be diagnosed at stage IV than non-NENs. Conclusion Advanced stage at diagnosis with significantly poorer outcomes of some NENs compared with non-NENs at the same anatomical site, highlight the need for improved access to specialist services and targeted service improvement.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
Publisher:	Springer Nature [academic journals on nature.com]
ISSN:	0007-0920
Date of Acceptance:	1 October 2019
Last Modified:	12 Mar 2025 17:00
URI:	https://orca.cardiff.ac.uk/id/eprint/176561

Actions (repository staff only)

Edit Item