A 10 year service evaluation of the survival of 439 patients with early oestrogen receptor positive breast cancer who underwent initial OncotypeDX ® testing to guide adjuvant chemotherapy decisions

Munir, Asma, Holt, Simon, Huws, Anita Marie, Khan, Sohail, Davies, Mark, Khawaja, Saira and Sharaiha, Yousef 2023. A 10 year service evaluation of the survival of 439 patients with early oestrogen receptor positive breast cancer who underwent initial OncotypeDX ® testing to guide adjuvant chemotherapy decisions. Cancer Treatment and Research Communications 34 , 100671. 10.1016/j.ctarc.2022.100671

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Abstract

Objective: To explore the long-term outcome of patients who underwent Oncotype DX® testing. The relationship between the RS, adjuvant treatments received, and clinical outcomes across the entire range of RS results are reported. Methods: 10-year Kaplan–Meier estimates for distant recurrence/BC-specific survival (BCSS) in this cohort. The analysis included 439 patients. The follow-up time ranged from 14 to 142 months. All analyses were performed using the SPSS v20. Results: More than half of patients had low RS (<18) (55.6%) and 15.3% had RS ≥ 31. Chemotherapy use was consistent with the RS with 4.4%, 7.1%, 28.0%, 71.4% and 91.0% receiving adjuvant chemotherapy in patients with RS < 11, 11–17, 18–25, 26–30, and ≥31, respectively. The overall chemotherapy rate was 27.6%. Distant metastasis free survival (DMFS) differed significantly (P < 0.001) between the RS groups with 10 year DMFS rates of 99% (SE +/- 0.01) in the RS<11, 97% (SE +/- 0.03) in the RS 11–17, 97% (SE +/- 0.02) in the RS 18–25, 85% (SE +/- 0.1) in the RS 26–30 and 74% (SE +/- 0.08) in the RS ≥ 31 group. Ten year breast cancer specific survival also differed significantly (P < 0.001) between the RS groups; this risk was 100% (no deaths from breast cancer reported in the first 10 years) in RS < 11, 95% (SE +/- 0.03) in RS 11–17, 94% (SE +/- 0.04) in RS 18–25, 93% (SE +/- 0.07) in RS 26–30, and 79% (SE +/- 0.07) in the RS ≥ 31 group. Conclusions: Use of Oncotype DX RS does guide the treatment decisions and correlates with the BCSS and disease-free survival for ER positive, Her2 negative, early-stage, node negative breast cancer patients.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Medicine
ISSN:	2468-2942
Date of First Compliant Deposit:	11 March 2025
Last Modified:	11 Mar 2025 12:15
URI:	https://orca.cardiff.ac.uk/id/eprint/176592

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