Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM

Cornely, Oliver A., Sprute, Rosanne, Bassetti, Matteo, Chen, Sharon C-A, Groll, Andreas H., Kurzai, Oliver, Lass-Flörl, Cornelia, Ostrosky-Zeichner, Luis, Rautemaa-Richardson, Riina, Revathi, Gunturu, Santolaya, Maria E., White, P. Lewis, Alastruey-Izquierdo, Ana, Arendrup, Maiken C., Baddley, John, Barac, Aleksandra, Ben-Ami, Ronen, Brink, Adrian J., Grothe, Jan H., Guinea, Jesus, Hagen, Ferry, Hochhegger, Bruno, Hoenigl, Martin, Husain, Shahid, Jabeen, Kauser, Jensen, Henrik E., Kanj, Souha S., Koehler, Philipp, Lehrnbecher, Thomas, Lewis, Russell E., Meis, Jacques F, Nguyen, M Hong, Pana, Zoi D., Rath, Peter-Michael, Reinhold, Ilana, Seidel, Danila, Takazono, Takahiro, Vinh, Donald C., Zhang, Sean X., Afeltra, Javier, Al-Hatmi, Abdullah M. S., Arastehfar, Amir, Arikan-Akdagli, Sevtap, Bongomin, Felix, Carlesse, Fabianne, Chayakulkeeree, Methee, Chai, Louis Y. A., Chamani-Tabriz, Leili, Chiller, Tom, Chowdhary, Anuradha, Clancy, Cornelius J., Colombo, Arnaldo L., Cortegiani, Andrea, Corzo Leon, Dora E., Drgona, Lubos, Dudakova, Anna, Farooqi, Joveria, Gago, Sara, Ilkit, Macit, Jenks, Jeffrey D., Klimko, Nikolai, Krause, Robert, Kumar, Anil, Lagrou, Katrien, Lionakis, Michail S., Lmimouni, Badre E., Mansour, Michael K., Meletiadis, Joseph, Mellinghoff, Sibylle C., Mer, Mervyn, Mikulska, Malgorzata, Montravers, Philippe, Neoh, Chin Fen, Ozenci, Volkan, Pagano, Livio, Pappas, Peter, Patterson, Thomas F., Puerta-Alcalde, Pedro, Rahimli, Laman, Rahn, Sebastian, Roilides, Emmanuel, Rotstein, Coleman, Ruegamer, Tamara, Sabino, Raquel, Salmanton-García, Jon, Schwartz, Ilan S., Segal, Esther, Sidharthan, Neeraj, Singhal, Tanu, Sinko, Janos, Soman, Rajeev, Spec, Andrej, Steinmann, Joerg, Stemler, Jannik, Taj-Aldeen, Saad J., Talento, Alida Fe, Thompson, George R., Toebben, Christina, Villanueva-Lozano, Hiram, Wahyuningsih, Retno, Weinbergerová, Barbora, Wiederhold, Nathan, Willinger, Birgit, Woo, Patrick C. Y. and Zhu, Li-Ping 2025. Global guideline for the diagnosis and management of candidiasis: an initiative of the ECMM in cooperation with ISHAM and ASM. The Lancet Infectious Diseases 10.1016/S1473-3099(24)00749-7

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Abstract

Candida species are the predominant cause of fungal infections in patients treated in hospital, contributing substantially to morbidity and mortality. Candidaemia and other forms of invasive candidiasis primarily affect patients who are immunocompromised or critically ill. In contrast, mucocutaneous forms of candidiasis, such as oral thrush and vulvovaginal candidiasis, can occur in otherwise healthy individuals. Although mucocutaneous candidiasis is generally not life-threatening, it can cause considerable discomfort, recurrent infections, and complications, particularly in patients with underlying conditions such as diabetes or in those taking immunosuppressive therapies. The rise of difficult-to-treat Candida infections is driven by new host factors and antifungal resistance. Pathogens, such as Candida auris (Candidozyma auris) and fluconazole-resistant Candida parapsilosis, pose serious global health risks. Recent taxonomic revisions have reclassified several Candida spp, potentially causing confusion in clinical practice. Current management guidelines are limited in scope, with poor coverage of emerging pathogens and new treatment options. In this Review, we provide updated recommendations for managing Candida infections, with detailed evidence summaries available in the appendix. [Abstract copyright: Copyright © 2025 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.]

Item Type:	Article
Date Type:	Published Online
Status:	In Press
Schools:	Schools > Medicine
Publisher:	Elsevier
ISSN:	1473-3099
Date of First Compliant Deposit:	5 March 2025
Date of Acceptance:	8 November 2024
Last Modified:	05 Mar 2025 11:16
URI:	https://orca.cardiff.ac.uk/id/eprint/176636

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