Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: a prospective observational cohort study

Ayling, Kieran, Jackson, Hannah, Jia, Ru, Royal, Simon, Fairclough, Lucy and Vedhara, Kavita 2025. Psychological correlates of antibody response to mRNA SARS-CoV-2 vaccination: a prospective observational cohort study. Brain, Behavior, and Immunity 127 , pp. 103-109. 10.1016/j.bbi.2025.03.011

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Abstract

Background Vaccines fundamentally changed the course of the COVID-19 pandemic, saving > 14 million lives within a year. However, vaccine-conferred protection showed inter-individual variability, with many identified correlates of protection (e.g., age) not amenable to change. This prospective observational cohort study examined whether modifiable psychological factors (depressive symptoms, anxiety, perceived stress and positive mood), which predict antibody responses to other vaccines, also influenced the effectiveness of COVID-19 vaccines. We focussed on novel mRNA vaccines as these conferred greater clinical protection and psychological correlates have not been investigated in these vaccines previously. Methods One-hundred and eighty-four adults attending a mass-vaccination centre in the UK received a two-dose BNT162b2 mRNA SARS-CoV-2 vaccine course, completed validated psychological measures, and provided blood samples prior to vaccination and 4 weeks following the second vaccine dose. Results In separate linear regression models controlling for pre-vaccination antibody levels, demographic and clinical factors, higher levels of depressive symptoms (β = -0.15 [95 % CI: −0.30, −0.01], p = 0.041, partial f2 = 0.009) and lower levels of positive mood (β = 0.16 [95 % CI: 0.01, 0.30], p = 0.036, partial f2 = 0.011) were significantly associated with lower SARS-CoV-2 spike-specific antibody levels following vaccination. No significant relationships were observed between measures of anxiety or perceived stress and antibody responses. Conclusions Lower levels of depressive symptoms and greater positive mood were associated with larger antibody responses following mRNA SARS-CoV-2 vaccination in a community sample attending for their first course of COVID-19 vaccinations. As both are amenable to change, they could offer mechanisms for enhancing vaccine effectiveness particularly among populations at greater risk of vaccine failure.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Psychology
Publisher:	Elsevier
ISSN:	0889-1591
Date of First Compliant Deposit:	17 March 2025
Date of Acceptance:	6 March 2025
Last Modified:	18 Mar 2025 11:31
URI:	https://orca.cardiff.ac.uk/id/eprint/176928

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