Isolated splenic sarcoidosis: a rare cause of hypercalcaemia in a patient with type 1 diabetes

Ullah, Hafiz Muhammad Zubair, Surya, Ashutosh, Morley, Nicholas ORCID: https://orcid.org/0000-0001-9261-9385 and Ahmad, Sajjad 2021. Isolated splenic sarcoidosis: a rare cause of hypercalcaemia in a patient with type 1 diabetes. BMJ Case Reports 14 (10) , e245987. 10.1136/bcr-2021-245987

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Abstract

A 30-year-old man was admitted to Intensive Therapy Unit (ITU) with status epilepticus secondary to severe hypoglycaemia on a background of type 1 diabetes. CT of the brain showed generalised cerebral oedema. He was successfully stepped down to a medical ward after 2 weeks. He was noted to have persistently high calcium, which required multiple doses of pamidronate. Parathyroid hormone level was appropriately low. CT of the thorax, abdomen and pelvis showed mild hepatosplenomegaly with small pathological lymph nodes throughout the abdomen. Bone marrow biopsy was unremarkable. Lymph node biopsy was difficult to achieve, and therefore a positron emission tomography scan was arranged. This showed an enlarged and hypermetabolic spleen. Differential diagnoses at this point included lymphoma and sarcoidosis. He underwent diagnostic splenectomy, and the diagnosis of sarcoidosis was confirmed histologically. Calcium level remained normal 17 months after splenectomy.

Item Type:	Article
Date Type:	Publication
Status:	Published
Schools:	Schools > Biosciences
Publisher:	BMJ Publishing Group
ISSN:	1757-790X
Date of Acceptance:	27 September 2021
Last Modified:	02 Apr 2025 15:45
URI:	https://orca.cardiff.ac.uk/id/eprint/177246

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