NMR crystallization: The application of NMR strategies to monitor the evolution of crystallization processes

Harris, Kenneth D.M. ORCID: https://orcid.org/0000-0001-7855-8598 and Hughes, Colan E. 2025. NMR crystallization: The application of NMR strategies to monitor the evolution of crystallization processes. Bryce, David L., ed. Modern NMR Crystallography: Concepts and Applications, Vol. 36. New Developments in NMR, Royal Society of Chemistry, pp. 342-371. (10.1039/9781837673179-00342)

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Abstract

The development of NMR strategies to explore the time-evolution of crystallization processes promises to yield significant insights into mechanistic aspects of crystallization phenomena. In recent years, there has been progress in the development of in situ solid-state NMR strategies that selectively detect the solid phase in heterogeneous solid/liquid systems of the type that exist during crystallization from solution, and these techniques have been demonstrated as a versatile approach to identify and characterize solid phases (crystalline and/or amorphous) that arise as transient intermediates on crystallization pathways. In situ NMR approaches for studying crystallization also include the CLASSIC NMR strategy, which yields essentially simultaneous information on the time-evolution of both the solid and liquid phases during crystallization from solution. In addition to providing insights into the structural evolution of the solid phase, this approach reveals the complementary changes that occur in the liquid phase (such as changes in speciation and interactions) during crystallization. An ex situ strategy that exploits the sensitivity advantages of solid-state DNP NMR in the study of crystallization systems is also discussed. This chapter presents an overview of the range of NMR techniques that have been utilized to monitor crystallization processes, highlighting the application of these techniques across a range of areas of materials science.

Item Type:	Book Section
Date Type:	Publication
Status:	Published
Schools:	Schools > Chemistry
Additional Information:	Chapter 12
Publisher:	Royal Society of Chemistry
ISBN:	978-1-83767-066-6
Last Modified:	03 Apr 2025 15:39
URI:	https://orca.cardiff.ac.uk/id/eprint/177376

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