JMM Profile: Mycoplasma genitalium: a small, yet significant pathogen

Rudman, Tia, Rowlands, Richard S., Jensen, Jorgen S. and Beeton, Michael L. 2025. JMM Profile: Mycoplasma genitalium: a small, yet significant pathogen. Journal of Medical Microbiology 74 (4) , 001984. 10.1099/jmm.0.001984

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Abstract

Graphical abstract Mycoplasma genitalium infections are enabled by multiple virulence factors, both intracellular and expressed on the cholesterol-containing phospholipid membrane. Intracellular accessory proteins form the tip structure, which adheres to epithelial cells in vivo via the transmembrane adhesion complex of Nap proteins, P110 and P140. Protein M binds to the Fab region of immunoglobulins with a high affinity to both λ and κ chains, enabling immune system evasion. Membrane lipoproteins and extracellular polymeric substances help in biofilm formation, which is thought to facilitate infection persistence.

Item Type:	Article
Date Type:	Published Online
Status:	Published
Schools:	Schools > Biosciences
Publisher:	Microbiology Society
ISSN:	0022-2615
Date of First Compliant Deposit:	16 April 2025
Date of Acceptance:	18 February 2025
Last Modified:	16 Apr 2025 11:33
URI:	https://orca.cardiff.ac.uk/id/eprint/177733

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