Ricketts, Alastair, Montgomery, Dorothy, Loeffler, Juergen, Barnes, Rosemary, Cruciani, Mario, Donnelly, J. Peter and White, P. Lewis
2025.
A longitudinal study assessing Aspergillus PCR performance through participation of external quality assessment schemes from 2019 to 2022.
Medical Mycology
63
(5)
, myaf036.
10.1093/mmy/myaf036
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Abstract
Aspergillus PCR now employs standardised methodology and commercial options, with clinical performance validated through meta-analyses. The long-term availability of external quality assessment schemes drives performance and provides a currently untapped source of technical data. The Fungal PCR initiative and the Quality Control for Molecular diagnostics (QCMD) combined forces to evaluate data from the Aspergillus PCR QCMD schemes between 2019-2022. Analysis showed inferior detection of non-fumigatus Aspergillus species (i.e., A. niger) compared with A. fumigatus. Longitudinal evaluation showed the use of “in-house” PCR methods by new participants when testing plasma generated lower positivity rates compared to commercial assays.
Item Type: | Article |
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Date Type: | Publication |
Status: | Published |
Schools: | Schools > Medicine |
Publisher: | Oxford University Press |
ISSN: | 1369-3786 |
Date of First Compliant Deposit: | 21 May 2025 |
Date of Acceptance: | 10 April 2025 |
Last Modified: | 21 May 2025 08:45 |
URI: | https://orca.cardiff.ac.uk/id/eprint/177977 |
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